pharmachologic effect
Korilip is a combination drug, the effect of which is determined by the effects of its constituent vitamins and coenzymes, as well as their synergistic effect.

Cocarboxylase hydrochloride (coenzyme) catalyzes the carboxylation and decarboxylation of α-keto acids, participates in the processes of carbohydrate metabolism, and through participation in the pentose cycle indirectly promotes the synthesis of nucleic acids, proteins, and lipids.

Activates tissue metabolism. The drug is used for correction of metabolic acidosis, cellular hypoxia, other metabolic disorders, insufficiency of liver, kidney, cardiovascular system function, and chronic intoxication.

Riboflavin (vitamin B2) as a coenzyme of flavin proteins is involved in the regulation of redox reactions, as well as in the processes of carbohydrate, protein and fat metabolism, plays an important role in the synthesis of hemoglobin and in maintaining normal visual function of the eye, the condition of the mucous membranes and skin.

Lipoic acid is involved in the oxidative decarboxylation of pyruvic acid and β-keto acids, in the regulation of lipid and carbohydrate metabolism, and plays an important role in the process of energy formation in the body. Lipoic acid has a hepatoprotective effect, improves the detoxification function of the liver, and protects against the effects of exo- and endotoxins.

Korilip improves tissue metabolism in various physiological and pathological conditions that require correction with cofactors and substrates.

Indications
As an independent treatment or as an addition to basic therapy for various pathological conditions in children, including:
- Chronic tissue hypoxia.
- Decreased immunity.
- Bacterial and viral infections.
- Chronic somatic diseases.
- Chronic intoxication.
- Conditions after suffering serious illnesses.
- Malnutrition (hypotrophy).

Contraindications
- Hypersensitivity reactions to the components included in the drug.
- Inflammation or bleeding in the rectum (contraindication related to the route of administration).

How to take, course of administration and dosage
The drug is administered rectally.

Having freed it from the package, insert the suppository into the anus (after preliminary bowel movement).

Children of early and preschool age (from 1 year to 6 years) - 1 suppository per day.

Children from 6 to 14 years old - 1-2 suppositories per day.

The duration of the course of treatment is 10 days. The total duration of treatment is 3-4 courses with an interval of 20 days (3-4 months).

Special instructions
The criteria for the duration of treatment, along with the clinical condition, are cytochemical indicators of the activity of peripheral blood leukocyte enzymes (succinate dehydrogenase and glycerophosphate dehydrogenase).

Release form
Rectal suppositories

Storage conditions
In a place protected from light, at a temperature below 9 °C
Best before date
2 years
Active substance
Cocarboxylase, Riboflavin, Thioctic acid