The active ingredient of Decaris - levamisole - is an anthelmintic agent.Acting on ganglion-like formations of nematodes, Dekaris causes depolarizing neuromuscular paralysis of the helminth muscle membrane, blocks succinate dehydrogenase, inhibits fumarate dehydrogenase, disrupting the course of bioenergetic processes of helminths. Thus, paralyzed nematodes are removed from the body by normal intestinal motility within 24 hours after taking the drug.

Pharmacokinetics

Levamisole, when taken orally at a dose of 50 mg, is rapidly absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is determined, on average, 1.5-2 hours after taking the drug. Levamisole undergoes intensive metabolism in the liver, its main metabolites are p-hydroxy-levamisole and its glucuronide. The half-life from the body is 3-6 hours.In unchanged form, less than 5% is excreted in urine, and less than 0.2% of the administered dose is excreted in feces.

Indications

Infections with helminths Ascaris lumbricoides, Necator americanus and Ancylostoma duodenale.

Contraindications

Hypersensitivity to one of the components of the drug. drug-induced agranulocytosis (history). children under 3 years of age. lactation period.For 150 mg tablets, children are contraindicated. Pregnancy Pregnant women should prescribe the drug only if the expected benefit outweighs the possible risk of using the drug. Lactation period To protect the newborn, it is necessary to decide whether to stop breastfeeding or stop taking the drug, depending on how necessary the drug is for the mother.Take with caution in case of liver or kidney failure, inhibition of bone marrow hematopoiesis.

Precautions

Decaris 150 mg tablets should not be administered to children. During pregnancy, Decaris should be prescribed only if the expected benefit to the mother outweighs the possible risk to the fetus. During and after taking Dekaris, drinking alcoholic beverages is not allowed for 24 hours.When driving a car or working in places of increased danger, you need to take into account that the drug Dekaris can cause transient mild dizziness.

Use during pregnancy and breastfeeding

Pregnancy. Pregnant women should prescribe the drug only if the expected benefit outweighs the possible risk of using the drug. Lactation period.To protect the newborn, a decision must be made whether to stop breastfeeding or stop taking the drug, depending on how necessary the drug is for the mother. Take with caution in case of liver and/or kidney failure, inhibition of bone marrow hematopoiesis.

Method of administration and dosage

Tablets 50 mg: Children from 3 to 6 years (10-20 kg) - 25-50 mg (12-1 tablet). from 6 to 10 years (20-30 kg) 50-75 mg (1-1.5 tablets).from 10 to 14 years (30-40 kg) - 75-100 mg (1.5-2 tablets) once. It is advisable to take the drug after meals with a small amount of water, in the evening. There is no need to take laxatives or a special diet. If necessary, the drug can be repeated after 7-14 days. Tablets 150 mg. Adults are prescribed one 150 mg tablet once. It is advisable to take the drug after meals with a small amount of water, in the evening.There is no need to take laxatives or a special diet. If necessary, the drug can be repeated after 7-14 days.

Side effects

Headache, insomnia, dizziness, palpitations, convulsions, dyspeptic symptoms such as nausea, vomiting, abdominal pain, diarrhea.There are reports of the development of central nervous system phenomena (encephalopathy) 2-5 weeks after taking the drug, as well as allergic reactions (skin rash), convulsions. In most patients, this phenomenon was reversible, and early use of glucocorticosteroid therapy improved the prognosis. The connection of these symptoms with taking Decaris is not entirely convincing.When using large doses or with long-term therapy, leukopenia, agranulocytosis, tremor may occur

Overdose

Symptoms: When a large dose of levamisole (over 600 mg) was administered, the following signs of intoxication were described: nausea, vomiting, drowsiness, convulsions, diarrhea, headache, dizziness and confusion.Treatment: In case of accidental overdose - if not much time has passed after taking the drug - you can rinse the stomach. Monitoring of vital signs and symptomatic therapy are necessary. If there are signs of anticholinesterase action, atropine can be administered.

Interaction with other drugs

When taking the drug simultaneously with alcoholic beverages, disulfiram-like phenomena are observed.Caution is required when using Decaris with drugs that affect hematopoiesis. When taking the drug simultaneously with coumarin-like anticoagulants, the prothrombin time may be prolonged, so it is necessary to adjust the dose of the oral anticoagulant. Decaris increases the level of phenytoin in the blood, therefore, when using them simultaneously, it is necessary to monitor the level of phenytoin in the blood.Decaris should not be used simultaneously with lipophilic drugs such as carbon tetrachloride, tetrachlorethylene, chenopodium oil, chloroform or ether, as its toxicity may increase.

Special instructions

During and after taking the drug, you should not drink alcohol for 24 hours. It has not been proven that levamisole, used as an anthelmintic, depresses the nervous system.

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